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The majority of the downgrades can be attributed to inconsistency resulting from great heterogeneity and the indirectness of the diversity of interventions (Table S5)

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Because Matrixyl and GHK-Cu operate through entirely different mechanisms matrikine signaling versus gene regulation there is no direct molecular competition between them

We also appreciate the feedback regarding the importance of expanding focus beyond 30-day readmission measures to emphasize long-term, chronic care management for heart failure patients